Solid phase synthesis of oligonucleotide phosphorothioate analogues using 3-methyl-1,2,4-dithiazolin-5-one (MEDITH) as a new sulfur-transfer reagent

Authors
Zhang, ZD Nichols, A Tang, JX Han, YX Tang, JY
Citation
Zd. Zhang et al., Solid phase synthesis of oligonucleotide phosphorothioate analogues using 3-methyl-1,2,4-dithiazolin-5-one (MEDITH) as a new sulfur-transfer reagent, TETRAHEDR L, 40(11), 1999, pp. 2095-2098
Citations number
18
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
11
Year of publication
1999
Pages
2095 - 2098
Database
ISI
SICI code
0040-4039(19990312)40:11<2095:SPSOOP>2.0.ZU;2-0
Abstract
A new sulfur-transfer reagent, 3-methyl-1,2,4-dithiazolin-5-one (MEDITH), h as been used for the synthesis of oligonucleotide phosphorothioates via sol id phase phosphoramidite approach. (C) 1999 Elsevier Science Ltd. All right s reserved.