Triazenes as robust and simple linkers for amines in solid-phase organic synthesis

A new linker strategy for the attachment of aliphatic amines has been devel oped. Starting from Merrifield resin, an immobilized diazonium salt was pre pared in two steps. Reaction of various amines gave rise to triazenes, whic h in turn were cleaved off upon treatment with mild acids. The triazenes ha ve been proven to be base stable and were used in various types of transfor mations. The overall process is high-yielding and efficient. (C) 1999 Elsev ier Science Ltd. All rights reserved.