Efficient catalytic enantioselective Mannich-type reactions using a zirconium-bis(binaphthol)methane complex

Authors
Ishitani, H Kitazawa, T Kobayashi, S
Citation
H. Ishitani et al., Efficient catalytic enantioselective Mannich-type reactions using a zirconium-bis(binaphthol)methane complex, TETRAHEDR L, 40(11), 1999, pp. 2161-2164
Citations number
8
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
11
Year of publication
1999
Pages
2161 - 2164
Database
ISI
SICI code
0040-4039(19990312)40:11<2161:ECEMRU>2.0.ZU;2-U
Abstract
In the presence of a catalytic amount of a zirconium-bis(binaphthol)methane complex (5), Mannich-type reactions of aldimines with silyl enolates proce eded smoothly to afford the corresponding adducts in high yields with high enantiomeric excesses. (R)-(R)-Bis(3-BINOL)methane 6, that was prepared by linking two binaphthols, was shown to be very effective in these reactions. (C) 1999 Elsevier Science Ltd. All rights reserved.