Preparation of amino acid appended cholic acid derivatives as sensitizers of Gram-negative bacteria

Attachment of amino acids to cholic acid derivatives yielded compounds that sensitize Gram-negative bacteria to hydrophobic antibiotics. Incorporation of three amino acid onto a cholic acid derivative via ester bonds was only achieved with non-alpha-branched amino acids. Three non-alpha-branched or three alpha-branched amino acids were coupled to the steroid backbone via a mide bonds. (C) 1999 Elsevier Science Ltd. All rights reserved.