A versatile synthesis of substituted tetrahydropyridines

Authors
Schurer, SC Blechert, S
Citation
Sc. Schurer et S. Blechert, A versatile synthesis of substituted tetrahydropyridines, TETRAHEDR L, 40(10), 1999, pp. 1877-1880
Citations number
22
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
10
Year of publication
1999
Pages
1877 - 1880
Database
ISI
SICI code
0040-4039(19990305)40:10<1877:AVSOST>2.0.ZU;2-F
Abstract
A short and efficient synthesis of highly substituted tetrahydropyridines i s achieved by a combination of enyne cross metathesis and aza-Diels-Alder r eaction under high pressure. The reaction sequence shows atom economy and i s compatible with a variety of functionalities being introduced by three bu ilding blocks: a monosubstituted alkyne, a terminal alkene, and an imine. ( C) 1999 Elsevier Science Ltd. All rights reserved.