A renal allograft recipient with late recurrence of focal and segmental glomerulosclerosis after switching from cyclosporine to tacrolimus

Background. Focal and segmental glomerulosclerosis (FSGS) is one of the mos t frequent and severe primary glomerulonephritis that recurs in transplante d kidneys. Although cyclosporine seems to have no effect on the frequency o f FSGS recurrence, there is evidence that cyclosporine reduces proteinuria and prolongs graft survival in patients with recurrent glomerulonephritis a fter renal transplantation. The effect of tacrolimus on nephrotic syndrome after renal transplantation is controversial. Methods. We describe the case of a 30-year-old man with steroid resistant n ephrotic syndrome due to FSGS who developed nephrotic syndrome 5 years afte r renal transplantation due to recurrent disease when he was switched from cyclosporine to tacrolimus. Results. He was given pulses of methylprednisolone and returned to cyclospo rine. His proteinuria decreased, but he rapidly developed chronic renal fai lure. Conclusions. This observation strongly suggests that tacrolimus should be g iven with considerable care in renal transplant recipients with FSGS.