The Need for Training when Using the NIH Stroke Scale: Large numbers of mul
ticentre acute stroke trials are under way or planned requiring a valid, ef
ficient, and reliable measure of patients' status and outcome. An establish
ed measure widely used in neurological deficits of acute stroke patients is
the National Institutes of Health Stroke Scale (NIHSS), which can reliably
be applied by well-trained raters. The question as to whether without syst
ematic training or detailed instructions the NIHSS is still reliable has no
t yet been addressed. Therefore we applied the NIHSS in 22 subacute stroke
patients. Two of the raters had been trained extensively, two raters had no
further information on the scale than given in the original NIHSS. The int
erobserver reliability among trained raters was substantial (kappa=0.61) an
d comparable to prior studies. Reliability was substantially poorer among t
he untrained raters (kappa=0.33) as well as between trained and untrained r
aters (K=0.45). Among the untrained raters a maximum difference between tot
al scores for the same patient of 4 or more points was found in 4 patients
and between trained and untrained raters even in 12 patients, Our results s
how, that the established good interrater reliability of the NIHSS applies
only to trained raters and not to untrained raters. One major problem for t
he untrained raters was the lack of instructions for the assessment of the
individual items gaze, visual field and dysarthria in comatose or obtunded,
unresponsive and aphasic patients. We conclude that the NIHSS cannot be re
liably applied whithout systematic training and knowledge of detailed instr
uctions. A standardised use of the NIHSS is mandatory in future trials.