Genomic imprinting: Implications for human disease

Genomic imprinting refers to an epigenetic marking of genes that results in monoallelic expression. This parent-of-origin dependent phenomenon is a no table exception to the laws of Mendelian genetics. Imprinted genes are intr icately involved in fetal and behavioral development. Consequently, abnorma l expression of these genes results In numerous human genetic disorders inc luding carcinogenesis. This paper reviews genomic imprinting and its role i n human disease. Additional information about imprinted genes can be found on the Genomic Imprinting Website at http://www.geneimprint.com.