S. Inghelbrecht et al., INSTRUMENTATION OF A ROLL COMPACTOR AND THE EVALUATION OF THE PARAMETER SETTINGS BY NEURAL NETWORKS, International journal of pharmaceutics, 148(1), 1997, pp. 103-115
A Fitzpatrick L83 Chilsonator was instrumented in order to understand
and to optimize the roll compaction process using drum-dried waxy maiz
e starch, a plastic deforming material as a model compound. The interr
elation of the four adjustable roll compactor parameter settings namel
y the velocity of the rolls OCS), the speed of the horizontal (HS) and
of the Vertical screw (VS), and the air pressure (P-air) influenced t
he compact and the granule quality. The granule quality was defined by
the friability and particle size distribution. As a second order poly
nomial was not successful to model the behaviour of the friability in
function of the four roll compactor parameters, a Multilayer Feed-Forw
ard neural network (MLF) was used. It was shown that the MLF network m
odels the friability more accurately than a second order polynomial. T
he HS and the P-air mostly influenced granule quality and should be ke
pt at a high level. The VS had no significant influence on compact qua
lity. (C) 1997 Elsevier Science B.V.