Vaginal stenosis following allogeneic bone marrow transplantation for acute myeloid leukaemia

We report the unusual complication of vaginal stenosis occurring after allo geneic bone marrow transplantation (BMT) for leukaemia. This was in all lik elihood a manifestation of chronic graft-versus-host disease (cGVHD), altho ugh the patient has no other stigmata of this and suffered little acute gra ft-versus-host disease (aGVHD) after BMT, Other risk factors for vaginal st enosis were considered and appear to be absent in this patient, although th e total body irradiation used as part of her conditioning therapy may play a role. We suggest that vaginal stenosis may be under-reported, since femal e patients suffer a number of gynaecological complications after BMT, and t hat regular questioning and examination may aid in making an earlier diagno sis, allowing speedier instigation of therapy and thus improving quality of life.