Neonatal examination and screening trial (NEST): a randomised, controlled,switchback trial of alternative policies for low risk infants

Objective To evaluate the effectiveness of one rather than two hospital neo natal examinations in detection of abnormalities. Design Randomised controlled switchback trial. Setting Postnatal wards in a teaching hospital in north east Scotland. Participants All infants delivered at the hospital between March 1993 and F ebruary 1995. Intervention A policy of one neonatal screening examination compared with a policy of two. Main outcome measures Congenital conditions diagnosed in hospital; results of community health assessments at 8 weeks and 8 months; outpatient referra ls; inpatient admissions; use of general practioner services; focused analy sis of outcomes for suspected hip and heart abnormalities. Results 4835 babies were allocated to receive one screening examination (on e screen policy) and 4877 to receive two (two screen policy). More congenit al conditions were suspected at discharge among babies examined twice (9.9 v 8.3 diagnoses per 100 babies; 95% confidence interval for difference 0.3 to 2.7). There was no no overall significant difference between the groups in use of community, outpatient, or inpatient resources or in health care r eceived. Although more babies who were examined twice attended orthopaedic outpatient clinics (340 (7%) v 289 (6%)), particularly for suspected congen ital dislocation of the hip (176 (3.6/100 babies) v 137 (2.8/100 babies); d ifference - 0.8; - 1.5 to 0.1), there was no significant difference in the number of babies who required active management (12 (0.2%) v 15 (0.3%)). Conclusions Despite more suspected abnormalities, there was no evidence of net health gain from a policy of two hospital neonatal examinations, Adopti on of a single examination policy would save resources both during the post natal hospital stay and through fewer outpatient consultations.