ROLE OF COAGULATION DISORDERS IN MESENTER IC ISCHEMIA

Mesenteric ischemic process can lead to bowel infarction or indolent l ow-grade ischemia. Inherited thrombophilia represents about 30 to 40 % of mesenteric vein thrombosis. Analysis of thromboembolism sites occu rring during genetic defect of coagulant factors showed that mesenteri c thrombosis is the third localization after lung and legs, in equal i ncidence with cerebral thrombosis. The genetic defects known to be ass ociated with thrombophilia, as deficiencies of protein C, protein S, a ntithrombin III, and dysfibrinogenemia, are discussed. A special inter est is devoted to resistance to activated protein C. Acquired diseases , as myeloproliferative disease or paroxysmal noctural hemoglobinemia, inducing thrombosis are also discussed. recent advances in both basic and clinical research have provided new insights that may be integrat ed into diagnostic and therapeutic practices.