Ring chromosomes in a malignant mesenchymoma

We report, for the first time, the cytogenetic and molecular genetic consti tution of a human mesenchymoma. As in several other soft tissue sarcomas, s upernumerary ring and rod-shaped marker chromosomes were observed next to a n otherwise normal diploid karyotype. Comparative genomic in situ hybridiza tion and whole chromosome painting experiments revealed that chromosome 1q2 1-q25 and 12q14-q15 sequences were amplified, and that these sequences resi ded on the supernumerary marker chromosomes. We assume that, in this malign ant mesenchymoma, the observed chromosomal anomalies map be associated with its well differentiated liposarcomatous component. (C) Elsevier Science in c., 1999. All rights reserved.