Premature centromere division in patients with multiple endocrine neoplasia type 1

Frequency of mitoses with premature centromere division (PCD) was examined in lymphocytes from subjects nifh multiple endocrine neoplasia type I (MEN I). An increase in PCD after exposure to an alkylating agent was observed i n subjects with MEN 1 who carry a heterozygous MEN1 gene mutation but not i n normal controls or in affected subjects without the MEN1 gene mutation. T hese findings support the inclusion of MEN1 as a chromosome instability syn drome and recognition of PCD as a manifestation of chromosome instability F urthermore, these results suggest that the MEN1 gene product may function t o maintain the integrity of DNA. (C) Elsevier Science Inc., 1999. All right s reserved.