SASRIN (TM), a versatile tool in peptide synthesis and solid-phase organicchemistry

The synthesis of the 4-(3-methoxy-4-(hydroxymethyl)phenoxymethyl) derivativ e of polystyrene-co-divinylbenzene (SASRIN(TM)), its derivatives and its ap plication in solid-phase peptide synthesis will be briefly reviewed in this paper. Solid-phase synthesis of fully protected peptide fragments may be t he most important, but by far not the only application, as cleavage with nu cleophiles or solid-phase synthesis on SASRIN derivatives will yield a rang e of useful C-terminally modified peptides, such as peptide hydrazides or p -nitroanilides.