Rapid progress in noninvasive ultrasound techniques has resulted in a wide
variety of clinical applications for assessment of both extracranial and in
tracranial arterial diseases. Recent highlights in cerebrovascular ultrasou
nd research include imaging methods for characterization of intracranial an
eurysms, use of echocontrast agents for improved evaluation of acute stroke
patients and transient response harmonic imaging for depiction of brain pe
rfusion. The important role of transcranial Doppler microembolism detection
in carotid endarterectomy has been defined, new approaches to noninvasive
Doppler measurement of intracranial pressure are progressing, and the clini
cal indications for transcranial Doppler monitoring of intracranial vasospa
sm to prevent secondary stroke have expanded. New functional transcranial D
oppler applications, which are complementary to positron emission tomograph
y and functional magnetic resonance imaging studies, are evolving for evalu
ation of functional recovery after stroke; investigation of perfusion asymm
etries during complex spatial tasks; assessment of hemispheric dominance in
surgical candidates for epilepsy surgery; and elucidation of temporal patt
erns of regional neuronal activity. With increasing sophistication of cereb
rovascular ultrasound methodology, it is essential that standards for data
acquisition and interpretation be established. Three recent consensus meeti
ngs have provided detailed recommendations on quantification of carotid art
ery stenosis, on characterization of carotid artery plaques and on microemb
olism detection by transcranial Doppler. Curr Opin Neurol 12:57-63. (C) 199
9 Lippincott Williams & Wilkins.