S. Bawa et Mc. Scrutton, RELATIONSHIP BETWEEN THE SYSTEMS RESPONSIBLE FOR UPTAKE OF 5-HYDROXYTRYPTAMINE AND OF NORADRENALINE BY HUMAN BLOOD-PLATELETS, Platelets, 6(4), 1995, pp. 190-194
Human blood platelets carry a high affinity, but low capacity, saturab
le system for the uptake of noradrenaline, The uptake is partially Na dependent but cannot be categorised as uptake(1), It is distinct from
the uptake system responsible for 5-hydroxytryptamine transport into
the platelet since the selective inhibitors of the platelet uptake sys
tem for 5-hydroxytryptamine (citalopram, paroxetine) differ from those
for the uptake system for noradrenaline (normetanephrine, methylisopr
enaline). 5-hydroxytryptamine inhibits noradrenaline uptake but with p
roperties inconsistent with competition for the same uptake system whi
le noradrenaline does not inhibit 5-hydroxytryptamine uptake. Neither
noradrenaline nor 5-hydroxytryptamine uptake by human platelets is inh
ibited by dopamine.