A novel synthetic anti-acute pancreatitis agent, IS-741

A novel synthetic drug, IS-741, inhibited cell adhesion in vitro and neutro phil in vivo. Thus, IS-741 inhibited the magnification of pancreatic lesion as well as progression to multiple organ failure in acute pancreatitis mod els. Furthermore, IS-741 at identical plasma concentrations equally improve d the survival rates in animals of various species with severe acute pancre atitis. Based on these observations, it was considered that IS-741 inhibite d tissue destruction by neutrophil after inhibiting neutrophil infiltration into the pancreas or other important organs in acute pancreatitis. II: was also considered that IS-741 demonstrated various anti-acute pancreatitis e ffects by interrupting a vicious cycle of inflammation. Therefore, IS-741 i s expected to become a useful drug for treating acute pancreatitis and mult iple organ failure in clinical settings.