Clinical significance of hepatic dysfunction with jaundice in typhoid fever

Citation
M. Khan et al., Clinical significance of hepatic dysfunction with jaundice in typhoid fever, DIG DIS SCI, 44(3), 1999, pp. 590-594
Citations number
34
Categorie Soggetti
Gastroenerology and Hepatology","da verificare
Journal title
DIGESTIVE DISEASES AND SCIENCES
ISSN journal
01632116 → ACNP
Volume
44
Issue
3
Year of publication
1999
Pages
590 - 594
Database
ISI
SICI code
0163-2116(199903)44:3<590:CSOHDW>2.0.ZU;2-Y
Abstract
A retrospective case note review was undertaken to assess the clinical sign ificance of hepatic dysfunction with jaundice in typhoid fever. Of the 57 p atients, 21 (36.8%) had jaundice, while 36 (63.2%) did not have jaundice. S ignificantly higher proportions of jaundiced patients were females (P = 0.0 4). Confusion (P = 0.01), upper abdominal pain (P = 0.02), right upper quad rant tenderness (P = 0.0001), and low prothrombin index (P = 0.04) were sta tistically significant occurrences in jaundiced patients on admission. Admi ssion mean values of serum bilirubin (P = 0.0001), gamma-glutamyltranspepti dase (GGT; P = 0.009), and alanine aminotransferase (ALT; P 0.0005) were si gnificantly higher in icteric patients while mean values of total serum pro tein (P 0.0009) and albumin (P = 0.0001) were significantly higher in anict eric patients. There were no deaths. Glomerulonephritis occurred significan tly (P 0.001) more frequently in icteric patients. It is concluded that hep atic dysfunction with jaundice in typhoid fever indicates more severe hepat ic injury, which may precipitate the development of clinically detectable g lomerulonephritis.