Applications of an acute assessment methodology used for combustion facilities

Authors
Citation
Hy. Chang, Applications of an acute assessment methodology used for combustion facilities, DRUG CHEM T, 22(1), 1999, pp. 25-39
Citations number
22
Categorie Soggetti
Pharmacology & Toxicology
Journal title
DRUG AND CHEMICAL TOXICOLOGY
ISSN journal
01480545 → ACNP
Volume
22
Issue
1
Year of publication
1999
Pages
25 - 39
Database
ISI
SICI code
0148-0545(1999)22:1<25:AOAAAM>2.0.ZU;2-#
Abstract
Two approaches for evaluating potential health impact from short-term (I ho ur) inhalation exposure to air emissions from combustion facilities are pre sented: This information was included as part of the health risk assessment (HRA) conducted for each proposed facility in conjunction with regulatory requirements for obtaining an operating permit. Since the facilities being evaluated have either not yet been constructed or are not yet operational, air concentrations (particulate and vapor) must first be estimated using da ta from similar and operational facilities. A chemical's modeled air concen tration was then compared to its acute toxicity value (ATV) selected from e stablished Occupational Exposure Limits (OEL) or acute toxicity databases, if available. Analogous to the current USEPA approach for estimating noncan cer health effects, acute hazard quotients (AHQs) were summed and compared to a level of one. When the summation of the AHQs exceeded unity, the chemi cals were separated by target organ and health effects based on acute expos ures. The author recognizes that the use of OELs has its limitations. Howev er, due to the lack of acute toxicity data and the advantage of the complet eness of the databases for OELs, this approach may be the best way to evalu ate for acute health concerns for the more than 70 compounds that may be em itted from these facilities.