Risk characterization is the final step of the risk assessment process as p
racticed in the U.S. EPA. In risk characterization, the major scientific ev
idence and "bottom-line" results from the other components of the risk asse
ssment process, hazard identification, dose-response assessment, and exposu
re assessment, are evaluated and integrated into an overall conclusion abou
t the risks posed by a given situation. Risk characterization is also an it
erative process; the results of a specific step may require re-evaluation o
r additional information to: finalize the risk assessment process. Risks po
sed by atmospheric emissions are an example of an involuntary human health
risk which typically receives a great deal of public attention. Characteriz
ation of the risks posed hv atmospheric emissions typically requires the us
e of mathematical models to evaluate: I) the environmental fate of emitted
pollutants, 2) exposures to these pollutants, and 3) human dose-response. I
ntegration of these models results in quantitative risk estimates. The conf
idence in a quantitative risk estimate is examined by evaluating uncertaint
y and variability within individual risk assessment components. Variability
arises from the true heterogeneity in characteristics within a population
or an event; on the other hand, uncertainty represents lack of knowledge ab
out the true value used in a risk estimate. U.S EPA's 1997 Mercury Study wi
ll illustrate some aspects of the risk characterization process as well as
the uncertainty and variability encountered in the risk assessment process.