Hazardous waste site managers and regulators can decide Easily,whether site
contamination requires remediation to protect human health, but defining t
he extent of cleanup is often an enormous challenge. When is the site clean
enough for human access and use? Risk assessment tools call be used to hel
p answer this question. One call calculate chemical-specific risk-based scr
eening levels (RBSLs) in environmental media (e.g. soil, water, and food) t
hat correspond to "acceptable" levels of risk. RBSLs can be calculated for
individual chemicals and chemical mixtures, specific to various exposure pa
thways. In calculating RBSLs, one must account for the fact that people may
be exposed to more than one chemical by more than one exposure pathway. Fa
te and transport models may be needed to predict how people might become ex
posed to site contamination in the future. Example RBSLs for non-cancer eff
ects are calculated to illustrate the utility and limitations of RBSLs for
making risk-based decisions at petroleum release sites.