Contribution of tridimensional sonography and magnetic resonance imaging to prenatal diagnosis of apert syndrome at mid-trimester

A diagnosis of Apert syndrome, suspected at 24 weeks' gestation after conve ntional sonography showing turribrachycephaly and syndactyly of hands and f eet, was confirmed at 26 weeks' gestation by tridimensional sonography and magnetic resonance imaging. This is only the second prenatal diagnosis repo rted at mid-trimester, excluding cases published from affected mothers or i n connection with a context of recurrence. Additional findings have been co llected from tridimensional sonography (mid-facial hypoplasia, downslanting palpebral fissures) and from magnetic resonance imaging (verticalization o f the clivus and flattened angle of the cranial base).