Prenatal diagnosis of congenital neuroblastoma - Analysis of 4 cases and review of the literature

Objective: Advances in prenatal diagnostics during the last 10 years have e nabled the examiner to detect even rare fetal disorders such as fetal tumou rs, Congenital neuroblastoma is the most frequent solid neoplasm in infancy , with a retroperitoneal cystic or solid mass being a sonographic sign of t he conditions. Methods: We present 4 cases of neuroblastoma showing suspici ous prenatal ultrasound findings. The investigation comprises detection dur ing pregnancy, typical sonographic signs, as well as the postnatal outcome, In addition, a review of the literature is undertaken with a focus on pren atal sonographic signs of congenital neuroblastomas. Results: In all 4 case s, a cystic tumour was detected during the 3rd trimester of pregnancy by me ans of B-mode sonography. One boy died of disseminated metastases at the ag e of 26 months, The other 3 survived after surgery and have remained health y, Conclusions: The detection of a cystic suprarenal mass is suspicious of a congenital neuroblastoma. The delivery should take place at a perinatal c entre.