Rc. Pillutla et al., Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR, GENOMICS, 56(2), 1999, pp. 217-220
Human p21/SIIR is a novel Ser/Arg/Pro-rich nuclear phosphoprotein that is 4
8% similar to transcription factor SII and modulates transcription in a pro
moter context-dependent fashion. We have obtained the complete sequence of
TCEAL1, the gene that codes for p21/SIIR. This gene consists of three exons
and two introns with the entire coding sequence in exon III. Tissue-specif
ic expression patterns of TCEAL1 by Northern blot analysis showed the prese
nce of an similar to 1.2-kb transcript in all normal human tissues examined
, and heart and skeletal muscle contained an additional transcript of simil
ar to 7 kb. Expression was lowest in hematopoietic cells of both normal and
tumor origin. TCEAL1 was mapped to human chromosome Xq22.1 by fluorescence
in situ hybridization. (C) 1999 Academic Press.