Limited research has been conducted to examine the effectiveness of existin
g HIV prevention and harm reduction interventions targeted to injection dru
g-using youth Moreover, although there are a growing number of needle excha
nge programs being developed for youth throughout the United States, the ef
fects of these services have yet to be systematically evaluated. This artic
le describes a collaborative evaluation conducted by the Division of Adoles
cent Medicine, Childrens Hospital Los Angeles, and Clean Needles Now, a nee
dle exchange serving young injection drug users. The evaluation employed a
multimethod research design that included both qualitative and quantitative
methods. Findings are presented about how a community-based agency's servi
ce delivery philosophy can affect the design and implementation of an evalu
ation. Lessons learned from this collaborative evaluation are presented, in
cluding the potential benefits of incorporating harm reduction principles i
nto research activities.