Despite the need for targeted HIV prevention interventions for prison inmat
es, institutional and access barriers have impeded development and evaluati
on of such programs. Over the past 6 years, the authors have developed a un
ique collaborative relationship to develop and evaluate HIV prevention inte
rventions for prison inmates. The collaboration includes an academic resear
ch institution (the Center for AIDS Prevention Studies at the University of
California, San Francisco), a community-based organization (Centerforce),
and the staff and inmate peer educators inside a state prison. In this ongo
ing collaboration, the authors have developed and evaluated a series of HN
prevention interventions for prison inmates and for women who visit prison
inmates. Results of these studies support the feasibility and effectiveness
of HIV prevention programs for inmates and their partners both in prison a
nd in the community. Access and institutional barriers to HIV intervention
research in prisons can be overcome through the development of collaborativ
e research partnerships.