Pregnancy after atrial repair for transposition of the great arteries

Objective-To investigate the risk of pregnancy in patients with transpositi on of the great arteries (TGA) who have undergone atrial repair. Design-Retrospective analysis (1962-94) of 342 TGA patients who underwent a trial repair. Of 231 known late survivors, 48 were women over 18 years old who were interviewed about possible reproductive plans and previous pregnan cies. As a control, comparison was made with data of 57 500 women (mean age 26 years) obtained from the Swiss Statistical Bank in Bern. Results-Mean follow up was 13.7 years; 66% remained asymptomatic, 29% had m ild to moderate cardiac symptoms, and 5% suffered from severe cardiac sympt oms (New York Heart Association grade III-IV). Thirty six of the 48 women w ished to bear children and, to date, there have been 10 live births, two sp ontaneous first trimester abortions, and one induced abortion at 16 weeks. During pregnancy there was one case of cardiac deterioration and two cases of pneumonia. There was no evidence of congenital heart disease in the chil dren. Conclusions-In this relatively small series the completion of pregnancy in women with TGA who had undergone atrial repair and who had normal functiona l cardiac status was uncomplicated.