Amoeba angeitic lesions of the central nervous system in Balamuthia mandrilaris amoebiasis

Balamuthia mandrilaris amoebiasis is a fatal disease: It primarily affects the nasal pyramid or the skin, producing granulomatous amoebic lesions. The amoeba spread from the primary nasal lesion to the meninges where they inf iltrate vessels. Thrombotic amoebic angitis produce infarcts of the central nervous system substance which then become infiltrated by amoeba. The prim ary cutaneous lesion can be present for weeks or even months. However, the appearance of neurological disease predicts a poor prognosis, in which deat h usually occurs within a few days or weeks. HUM PATHOL 30:269-273. Copyrig ht (C) 1999 by W.B. Saunders Company.