Prevalence and factors associated with tuberculosis infection among new school entrants, New York City, 1991-1993

SETTING: New York City public (or state-run) and private schools-elementary and secondary. OBJECTIVE: To describe the prevalence and determine factors associated with positive tuberculin skin tests (TSTs) in school children. DESIGN: Mandatory TST surveys among cohorts of new school entrants for the 1991, 1992 and 1993 school years, of whom birthplace was known for 81%. A p ositive tuberculin skin test defined as greater than or equal to 10 mm indu ration. RESULTS: Of the 298 506 new school entrants, 2.1% (6326) were tuberculin te st positive. The proportion that was tuberculin test positive was 0.5% (931 /199 728) among US-born and 9.2% (3794/41 346) among foreign-born students. Foreign-born (FB) students with a history of BCG vaccination were much mor e likely to have a positive tuberculin test than US-born students (13.6% vs . 0.5%, odds ratio [OR] = 33.6, 95% confidence interval [CT] 31.7, 35.6), a nd were more likely to have a positive tuberculin test than FB students wit h no history of BCG (13.6% vs. 4.4%, OR = 3.4, 95% CI 2.5, 4.6). Older age was independently associated with tuberculin test positivity, except among foreign-born BCG-vaccinated children, in whom the youngest were more likely to have a positive tuberculin test. CONCLUSIONS: Even in the midst of a tuberculosis resurgence such as that ex perienced by New York City, where tuberculosis cases nearly tripled from 19 78 to 1992, the risk of tuberculosis infection among school children remain ed quite low. Given the reduced predictive value of the tuberculin test amo ng low risk children and the effects of BCG vaccination, many children (esp ecially younger children) with positive tuberculin test results are probabl y not infected with Mycobacterium tuberculosis. To reduce unnecessary evalu ation and treatment, routine tuberculin tests should be administered only t o high risk groups such as older children from countries with high rates of tuberculosis.