I. Lemaire et al., Stimulation of interleukin-1 and -6 production in alveolar macrophages by the neotropical liana, Uncaria tomentosa (Una de Gato), J ETHNOPHAR, 64(2), 1999, pp. 109-115
Two extracts of different collections of the traditional medicine una de ga
to (Uncaria tomentosa) from Peru were characterized by High Pressure Liquid
Chromatography as containing approximately 6 mg/g total oxindole content p
rior to studies with alveolar macrophages. The plant preparations greatly s
timulated IL-1 and IL-6 production by rat macrophages in a dose dependent m
anner in the range of 0.025-0.1 mg/ml. They were also able to enhance IL-1
and -6 in lipopolysaccharide-stimulated macrophages. The results suggest a
strong immunostimulant action of this plant. (C) 1999 Published by Elsevier
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