Correlated responses to artificial selection for stress tolerance can provi
de insight into underlying genetic variation and the physiological basis of
stress resistance. Lines of Drosophila melanogaster held in the absence of
food or with an unsuitable resource, specifically decomposing lemon, respo
nded to selection by becoming starvation resistant. The lemon-selected line
s also adapted by evolving a resource-based induction response. Compared to
control lines, the selected lines tended to store more lipid, develop slow
er and have a larger body size. Additional responses included resistance to
desiccation and acetone fumes, suggesting multiple stress resistance is a
correlated result of selection for starvation resistance. The specific meta
bolic rate was lower in the starvation selected lines and enzyme activities
changed in response to selection. In particular, enzyme activities indirec
tly associated with lipid biogenesis increased in both types of selected li
nes. The correlated responses to the two selection regimes were sufficientl
y consistent to indicate a common basis for starvation resistance. Specific
responses to starvation selection appeared to oppose the short-term phenot
ypic responses to starvation. Thus, a common response to stress selection m
ay be to ameliorate the immediate physiological impact of the stress factor
.