The incorporation of velocity-encoding gradient pulses in RF-pulse trains i
s proposed and examined, Velocity selective perturbation is shown to be ana
logous in many respects to the well established use of trains of short RF-p
ulses for chemical shift selective perturbation. Velocity selective perturb
ation is viable in a biomedical setting only if additional RF refocusing pu
lses are inserted between the individual RF-pulse elements, Aspects of velo
city selective excitation saturation and inversion are examined, and new in
version pulse trains proposed. The selective perturbation of both flowing a
nd stationary spins is demonstrated in phantoms and possible biomedical app
lications of these pulse trains are discussed. (C) 1999 Academic Press.