Compatibility of tropisetron with glass and plastics. Stability under different storage conditions

The compatibility of tropisetron (pure undiluted 1 mg mL(-1) and diluted wi th 5% glucose or 0.9% NaCl (saline)) with glass, poly(vinyl chloride), poly propylene or polyethylene containers has been studied over a period of two weeks. The drug solutions were exposed to different light and temperature c onditions. Tropisetron was assayed by high-performance liquid chromatograph y. The results show that undiluted tropisetron is stable in polypropylene syri nges for two weeks under all the storage conditions tested (daylight at roo m temperature, dark at room temperature, refrigerator at 4 degrees C). Some variations in concentration were observed after dilution of tropisetron bu t these remained within 10% of the initial concentration. Tropisetron can b e stored undiluted at 1 mg mL(-1) in polypropylene syringes, although it is preferable to perform dilutions extemporaneously. Tropisetron diluted with 5% glucose or saline can be kept equally well in glass, poly(vinyl chlorid e) (Travenol bags) or polyethylene (ecoflac) containers.