Time scales for the formation of the most probable tertiary contacts in proteins with applications to cytochrome c

Authors
Thirumalai, D
Citation
D. Thirumalai, Time scales for the formation of the most probable tertiary contacts in proteins with applications to cytochrome c, J PHYS CH B, 103(4), 1999, pp. 608-610
Citations number
11
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
JOURNAL OF PHYSICAL CHEMISTRY B
ISSN journal
15206106 → ACNP
Volume
103
Issue
4
Year of publication
1999
Pages
608 - 610
Database
ISI
SICI code
1520-6106(19990128)103:4<608:TSFTFO>2.0.ZU;2-3
Abstract
A simple theory (practically without any adjustable parameter) for calculat ing the diffusion-limited rates of forming loops of arbitrary length in pol ypeptide chains is given. The time needed to form a tertiary contact betwee n met80 and his18 in Cytochrome c is 40 mu s, which is in excellent agreeme nt with experimental determinations.