Mv. Smith et Wf. Mcdonnell, A statistical model for FEV1 response to arbitrary dynamic ozone exposure conditions, J AIR WASTE, 49(3), 1999, pp. 289-298
Citations number
12
Categorie Soggetti
Environment/Ecology,"Environmental Engineering & Energy
Lung function response to inhaled ozone at ambient air pollution levels is
known to be a function of ozone concentration, exposure duration, and minut
e ventilation. Most data-driven exposure-response models address exposures
under static condition (i.e., with a constant ozone concentration and exerc
ise pattern). Such models are simplifications, as both ambient ozone concen
trations and normal human activity patterns change with time. The purpose o
f this study was to develop a dynamic model of response with the advantages
of a statistical model (a relatively simple structure with few parameters)
. A previously proposed mechanistic model for changes in specific airways r
esistance was adapted to describe the percent change in forced expiratory v
olume in one second (FEV1). This model was then reduced using the fit to th
ree existing exposure-response data sets as criterion. The resulting model
consists of a single linear differential equation together with an algebrai
c logistic equation. Under restricted static conditions the model reduces t
o a logistic model presented earlier by the authors.