Synthesis and biological evaluation of highly functionalized analogues of ingenol

Authors
Winkler, JD Kim, SH Harrison, S Lewin, NE Blumberg, PM
Citation
Jd. Winkler et al., Synthesis and biological evaluation of highly functionalized analogues of ingenol, J AM CHEM S, 121(2), 1999, pp. 296-300
Citations number
29
Categorie Soggetti
Chemistry & Analysis",Chemistry
Journal title
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
ISSN journal
00027863 → ACNP
Volume
121
Issue
2
Year of publication
1999
Pages
296 - 300
Database
ISI
SICI code
0002-7863(19990120)121:2<296:SABEOH>2.0.ZU;2-T
Abstract
The synthesis and preliminary biological evaluation of the first analogues of ingenol, a potent activator of protein kinase C, containing all of the o xygen functionality and unsaturation present in the natural product, is des cribed.