Poor treatment outcome of Philadelphia chromosome-positive pediatric acutelymphoblastic leukemia despite intensive chemotherapy

Authors
Uckun, FM Nachman, JB Sather, HN Sensel, MG Kraft, P Steinherz, PG Lange, B Hutchinson, R Reaman, GH Gaynon, PS Heerema, NA
Citation
Fm. Uckun et al., Poor treatment outcome of Philadelphia chromosome-positive pediatric acutelymphoblastic leukemia despite intensive chemotherapy, LEUK LYMPH, 33(1-2), 1999, pp. 101-106
Citations number
27
Categorie Soggetti
Hematology,"Onconogenesis & Cancer Research
Journal title
LEUKEMIA & LYMPHOMA
ISSN journal
10428194 → ACNP
Volume
33
Issue
1-2
Year of publication
1999
Pages
101 - 106
Database
ISI
SICI code
1042-8194(199903)33:1-2<101:PTOOPC>2.0.ZU;2-C
Abstract
Children with Philadelphia (Ph) chromosome positive ((+)) acute lymphoblast ic leukemia (ALL) represent a subgroup at very high risk for treatment fail ure. This study included 1322 children enrolled between 1988 and 1994 on CC G risk-adjusted studies for ALL who had centrally reviewed cytogenetic data . Thirty patients had a t(9;22) and are referred to as Phi; 1292 were Ph-. 23 of these 30 patients were treated on the CCG-1882 high risk ALL protocol . The event-free survival (EFS) outcome in CCG-1882 was significantly worse for Ph+ compared with Ph- patients, with 4-year estimates of 11.3% (SD = 9 .8%) and 73.4% (SD = 2.3%), respectively (p < 0.0001).