Synthesis and microbiological activities of pyrrole analogs of BM 212, a potent antitubercular agent

During the course of our investigations in the field of azole antimicrobial agents, we identified BM 212 a pyrrole derivative with good in vitro activ ity against mycobacteria and candidae. These findings prompted us to prepar e a series of new pyrrole derivatives in the hope of increasing activity; t heir synthesis and antimicrobial activity are described in this paper. Some of the synthesized compounds showed interesting in vitro activity against Mycobacterium tuberculosis and atypical mycobacteria.