IN-VITRO CULTURE OF HUMAN THYROID-CELLS - PRELIMINARY FINDINGS ON THEROLE OF THE PATHOLOGICAL CONDITION OF THE DONORS

Although primary cultures of human thyroid cells are used for endocrin ological and toxicological studies, until now no attention has been pa id toward verifying whether the hormonal conditions to which the gland was exposed in vivo prior to surgery could influence in vitro respons es. Our findings suggest that the hormonal situation in vivo cannot be used as a predictive indicator of triiodothyronine and thyroxine rele ase and/or S-phase frequency in vitro, either with or without the addi tion of bovine thyrotropin.