SILENCERS AND LOCUS-CONTROL REGIONS - OPPOSITE SIDES OF THE SAME COIN

Authors
KAMAKAKA RT
Citation
Rt. Kamakaka, SILENCERS AND LOCUS-CONTROL REGIONS - OPPOSITE SIDES OF THE SAME COIN, Trends in biochemical sciences, 22(4), 1997, pp. 124-128
Citations number
41
Categorie Soggetti
Biology
Journal title
Trends in biochemical sciences → ACNP
ISSN journal
09680004
Volume
22
Issue
4
Year of publication
1997
Pages
124 - 128
Database
ISI
SICI code
0968-0004(1997)22:4<124:SALR-O>2.0.ZU;2-P
Abstract
Whether or not genes are in an active or a repressed state in a cell d epends on the relative effect of gene silencers and locus control regi ons (LCRs). Here, we suggest that these elements act as binary switche s; the state that prevails (activated or repressed) probably depends o n a competition between protein complex formation and the stability of the complexes formed at either of the two elements.