Conventional potato breeding does not make full use of the existing bi
odiversity within the Solanum genus. Moreover breeding at the 4x-4x le
vel is slow. The potential for breeding at the diploid and dihaploid l
evels has therefore been explored. This requires use of novel techniqu
es to overcome deviations from the desired Endosperm Balance Number. S
omatic hybridization approaches include symmetric and asymmetric hybri
dizations and cybridization. Interesting traits have been successfully
transferred through these techniques. Introgression and chromosome el
imination have profited from the recent and rapid development of analy
tical techniques such as RFLP and RAPD. Cellular approaches in potato
breeding may be combined with conventional breeding by a stepwise redu
ction of the ploidy level followed by resynthesis of a new heterozygou
s tetraploid clone. Such schemes have been used to include virus or ne
matode resistance. Haploids may be derived from different sources or o
btained through different techniques. Dihaploid-dihaploid breeding pro
grammes may be especially interesting. Because of this potential, cell
ular biology of potato deserves the continued interest of the scientif
ic community.