No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease

Authors
Wavrant-DeVrieze, F Rudrasingham, V Lambert, JC Chakraverty, S Kehoe, P Crook, R Amouyel, P Wu, W Holmans, P Rice, F Perez-Tur, J Frigard, B Morris, JC Carty, S Cottel, D Tunstall, N Lovestone, S Petersen, RC Chartier-Harlin, MC Goate, A Owen, MJ Williams, J Hardy, J
Citation
F. Wavrant-devrieze et al., No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease, NEUROSCI L, 262(2), 1999, pp. 137-139
Citations number
15
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE LETTERS
ISSN journal
03043940 → ACNP
Volume
262
Issue
2
Year of publication
1999
Pages
137 - 139
Database
ISI
SICI code
0304-3940(19990305)262:2<137:NABTAM>2.0.ZU;2-Z
Abstract
Recent reports have suggested that variability in the alpha 2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both t ested a common polymorphism in the gene (l1000V) for association with the d isease in a four-site case control study design, and tested the locus for l inkage in a large series of sibpairs afflicted with late onset disease. Our results fail to show an association between this polymorphism and disease. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.