Altered mechanics of cartilage with osteoarthritis: human osteoarthritis and an experimental model of joint degeneration

Objective: Studies of cartilage mechanics seek to determine the fundamental relationships between mechanical behavior and the composition and structur e of healthy cartilage and to determine mechanisms for changes associated w ith degeneration. Method: The mechanics of normal and osteoarthritic (OA) human articular car tilage are reviewed. Studies of the initiation and pathogenesis of cartilag e degeneration in the anterior cruciate ligament transection (ACLT) model o f joint instability are also presented. Results: In human cartilage with OA, tensile, compressive and shear behavio rs are dramatically altered. These changes present as decreases in the modu lus or stiffness of OA cartilage in tension, compression and shear loading, and increases in the propensity to swell as compared to healthy cartilage. In the ACL transaction model of OA, similar changes in the mechanics of ca rtilage have been observed. In addition, changes in structure, composition, and as metabolism consistent with human OA have been found. Deterioration of the collagen-proteoglycan solid network, which appears to be focused at the articular surface, has been the earliest cartilage changes in the model . It remains to be determined if the initial disruption of the cartilage su rface is a direct result of mechanical forces or a product of altered chond rocyte activity. Conclusions: These data and continued research using experimental models of OA provide a basis for our understanding of the pathogenesis and the time course of events in OA and will lead to the development of better procedure s for disease intervention and treatment.