An in vivo study investigated 2D and 3D relationships between global and lo
cal vertebral and discal descriptors of the scoliotic spine deformity. It w
as performed on a cohort of 40 patients representing a wide range of thorac
ic curve progression. Global descriptors referred to Cobb angle in PA view
as well as corresponding Cobb angle in the plane of maximum deformity and i
ts angular orientation. Local descriptors included vertebral axial rotation
, wedging angles in the global and local vertebral frontal planes as well a
s a 3D maximum wedging angle and its angular orientation. Statistical analy
ses indicated that, at the thoracic level, vertebral wedging and axial rota
tion increase with curve severity. The 3D maximum wedging tends to shift to
wards the left posterolateral vertebral region with curve severity, with si
multaneous displacement of the plane of maximum deformity toawrds die coron
al plane. These results confirm the importance of 3D measurements in the un
derstanding of biomechanics of idiopathic scoliosis.