The enantioselective total synthesis of epoformin and analogues

Authors
Barros, MT Maycock, CD Ventura, MR
Citation
Mt. Barros et al., The enantioselective total synthesis of epoformin and analogues, TETRAHEDRON, 55(11), 1999, pp. 3233-3244
Citations number
33
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
55
Issue
11
Year of publication
1999
Pages
3233 - 3244
Database
ISI
SICI code
0040-4020(19990312)55:11<3233:TETSOE>2.0.ZU;2-Y
Abstract
(+)-Epoformin 1 and (-)-theobroxide 2 belong to a family of highly oxygenat ed cyclohexane-based metabolites, mainly epoxides, that have been isolated from bacteria, fungi, higher plants and molluscs.(1-5) These compounds have stimulated several synthetic efforts(6-9) due to their biological activiti es, which range from antifungal, antibacterial, antitumor, phytotoxic and e nzyme inhibitory.(1-9).