The structural requirements for inhibition of proteasome function by the lactacystin-derived beta-lactone and synthetic analogs

Authors
Corey, EJ Li, WDZ Nagamitsu, T Fenteany, G
Citation
Ej. Corey et al., The structural requirements for inhibition of proteasome function by the lactacystin-derived beta-lactone and synthetic analogs, TETRAHEDRON, 55(11), 1999, pp. 3305-3316
Citations number
18
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
55
Issue
11
Year of publication
1999
Pages
3305 - 3316
Database
ISI
SICI code
0040-4020(19990312)55:11<3305:TSRFIO>2.0.ZU;2-F
Abstract
The synthesis of analogs of the lactacystin-derived beta-lactone (2) in whi ch the substituents at C(5), C(7) and C(9) were systematically varied has l ed to a well defined structure-activity correlation for the highly selectiv e inhibition of the mammalian 20 S proteasome. (C) 1999 Elsevier Science Lt d. All rights reserved.