Dianion equivalents corresponding to the polypropionate domain of epothilone B

Authors
Harris, CR Kuduk, SD Savin, K Balog, A Danishefsky, SJ
Citation
Cr. Harris et al., Dianion equivalents corresponding to the polypropionate domain of epothilone B, TETRAHEDR L, 40(12), 1999, pp. 2263-2266
Citations number
10
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
12
Year of publication
1999
Pages
2263 - 2266
Database
ISI
SICI code
0040-4039(19990319)40:12<2263:DECTTP>2.0.ZU;2-T
Abstract
A modified synthesis of the polypropionate portion of epothilone, which uti lizes a novel, diastereoselective aldol reaction of (S)-2-methyl-4-pentenal (4) and the Z-enolate of the tricarbonyl species (3) is reported. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.