A photolabile carbamate based dual linker analytical construct for facile monitoring of solid phase chemistry: 'TLC' for solid phase?

Authors
McKeown, SC Watson, SP Carr, RAE Marshall, P
Citation
Sc. Mckeown et al., A photolabile carbamate based dual linker analytical construct for facile monitoring of solid phase chemistry: 'TLC' for solid phase?, TETRAHEDR L, 40(12), 1999, pp. 2407-2410
Citations number
11
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
12
Year of publication
1999
Pages
2407 - 2410
Database
ISI
SICI code
0040-4039(19990319)40:12<2407:APCBDL>2.0.ZU;2-J
Abstract
A dual linker analytical construct based on a photolabile carbamate is desc ribed. Photochemical cleavage from the solid support can be effected to aff ord an analytical fragment, containing the substrate, which is sensitised t o electrospray mass spectrometry. We believe this simple construct now rend ers all substrates visible to high throughput mass specroscopic analysis. ( C) 1999 Elsevier Science Ltd. All rights reserved.