H-1 NMR study on putative intramolecular hydrogen bonding for histamine H-3-receptor agonists

Authors
Kovalainen, JT Christiaans, JAM Poso, A Vepsalainen, J Laatikainen, R Gynther, J
Citation
Jt. Kovalainen et al., H-1 NMR study on putative intramolecular hydrogen bonding for histamine H-3-receptor agonists, TETRAHEDR L, 40(12), 1999, pp. 2425-2428
Citations number
13
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
12
Year of publication
1999
Pages
2425 - 2428
Database
ISI
SICI code
0040-4039(19990319)40:12<2425:HNSOPI>2.0.ZU;2-U
Abstract
Conformational stabilization by intramolecular hydrogen banding of two hist amine H-3-receptor agonists is studied by H-1 NMR. Stabilization of each in dividual conformation of the compounds by intramolecular hydrogen bonding i s not strong at physiological pH and temperature. However, 52% - 61% of the molecules exist in conformations where an intramolecular hydrogen band is possible. (C) 1999 Elsevier Science Ltd. All rights reserved.